Kenshin and Kaoru are married. Kenshin leaves Kaoru with their son, Kenji, to lead a revolution in China. But both of them suffer from a seemingly incurable disease. 15 years later, Kenshin tries to return home to his wife before she dies of grief. Flashbacks of Kenshin's previous encounters with friends and foes occur while Kenshin struggles to make it back home.
The Meiji Era was one of great renewal for Japan, where swords and killing were outlawed. However, many survivors from the time of Revolution still live, lurking in the shadows and waiting for a chance to use their killing blades again. Only Kenshin Himura, formerly one of the most brutal of killers, hopes to keep his swordsman's honor and still live in the new era.