Edward and Alphonse Elric are two brothers gifted with the ability of alchemy, the science of taking one thing and changing it into another. However, alchemy works on the theory of Equivalent Exchange -- for something to be created, something else of equal value must be sacrificed. When their mother dies, Edward decides to do the unthinkable -- bringing her back to life by breaking one of Alchemy's biggest taboos and performing Human Alchemy. Thinking they have nothing more to lose, he and Alphonse make their attempt -- but something goes horribly wrong. In the process, Alphonse loses his body and Edward loses his leg. Ed manages to save Al by attaching his spirit to a suit of armor, but at the cost of his arm and leg.
Edward and Alphonse Elric's reckless disregard for alchemy's fundamental laws ripped half of Ed's limbs from his body and left Al's soul clinging to a cold suit of armor. To restore what was lost, the brothers scour a war-torn land for the Philosopher's Stone, a fabled relic which grants the ability to perform alchemy in impossible ways. The Elrics are not alone in their search; the corrupt State Military is also eager to harness the artifact's power. So too are the strange Homunculi and their shadowy creator. The mythical gem lures exotic alchemists from distant kingdoms, scarring some deeply enough to inspire murder. As the Elrics find their course altered by these enemies and allies, their purpose remains unchanged – and their bond unbreakable.